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Clin. Cardiol. 23, 831–836 (2000)

In-Hospital Mortality of Elderly Patients with Acute Myocardial Infarction: Data from the MITRA (Maximal Individual Therapy in Acute Myocardial Infarction) Registry

K.K. Haase, M.D., FACC, R. Schiele, M.D., S. Wagner, M.D., F. Fischer, M.D., U. Burczyk, M.D., R. Zahn, M.D., S. Schuster, M.D., J. Senges, M.D., FACC

Heart Center Ludwigshafen, Ludwigshafen, Germany


Background: Advanced age remains one of the principal determinants of mortality in patients with acute myocardial infarction (AMI).

Hypothesis: The aim of this study was to determine the in-hospital outcome of elderly (>75 years) patients with AMI who were admitted to hospitals participating in the national MITRA (Maximal Individual Therapy in Acute Myocardial Infarction) registry.

Methods: MITRA is a prospective, observational German multicenter registry investigating current treatment modalities for patients presenting with AMI. All patients with AMI admitted within 96 h of onset of symptoms were included in the MITRA registry. MITRA was started in June 1994 and ended in January 1997. This registry comprises 6,067 consecutive patients with a mean age of 65 ± 12 years, of whom 1,430 (17%) were aged >75 years. Patients were compared with respect to patient characteristics, prehospital delays, early treatment strategies, and clinical outcome.

Results: In the elderly patient population, the prehospital delay was 210 min, which was significantly longer than that for younger patients (155 min, p = 0.001). Although the incidence of potential contraindications for the initiation of thrombolysis was almost equally distributed between the two age groups (8.7 vs. 8.2%, p = NS), elderly patients (>75 years) received reperfusion therapy less frequently (35.9 vs. 64.6%) than younger patients. Mortality increased with advanced age and was 26.4% for all patients aged >75 years. If reperfusion therapy was initiated, in-hospital mortality was 21.8 versus 28.9% in patients aged >75 years (p = 0.001) and 29.4 versus 38.5% in patients aged >85 years (p = 0.001).

Conclusion: In this registry, elderly patients with AMI had a much higher in-hospital mortality than that expected from randomized trials. In MITRA, the mortality reduction with reperfusion therapy was found to be highest in the very elderly patient population.

Key words: acute myocardial infarction, early therapy, age

Address for reprints:
Dr. Karl K. Haase, M.D., FACC
Heart Center Ludwigshafen
Bremserstr. 79
D-67063 Ludwigshafen, Germany

Received: May 12, 1999
Accepted with revision: January 26, 2000

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